Comment on “Human White Blood Cells Synthesize Morphine: CYP2D6 Modulation”

Human white blood cells synthesize morphine: CYP2D6 modulation.

Human plasma contains low, but physiologically significant, concentrations of morphine that can increase following trauma or exercise. We now demonstrate that normal, human white blood cells (WBC), specifically polymorphonuclear cells, contain and have the ability to synthesize morphine. We also show that WBC express CYP2D6, an enzyme capable of synthesizing morphine from tyramine, norlaudanoso...

Surface Glycoproteins of Human White Blood Cells

We labeled surface glycoproteins of norby polyacrylamide slab gel electrophoresis. mal human blood platelets, granulocytes, All major types of human leukocytes monocytes, T and B lymphocytes, and null showed different and characteristic surcells by the galactose oxidase-NaB3H4 face glycoprotein patterns. These patterns and periodate-NaB3H4 labeling techevidently also include common comniques. T...

Human Endothelial Cells Synthesize Protein

Human umbilical vein endothelial cells were analyzed for the presence of prothrombin. factor VII, protein C, and protein S in culture supernatants and cell extracts using specific radioimmunoassays. Only protein S was detected. Conditioned medium from 24-hour cultures and cell lysates contained 21.7 ng/mL and 88.8 ng/107 cells of protein S, respectively. Intrinsic labeling and immunoprecipitati...

Human Microglial Cells Synthesize Albumin in Brain

Albumin, an abundant plasma protein with multifunctional properties, is mainly synthesized in the liver. Albumin has been implicated in Alzheimer's disease (AD) since it can bind to and transport amyloid beta (Abeta), the causative agent of AD; albumin is also a potent inhibitor of Abeta polymerization. Despite evidence of non-hepatic transcription of albumin in many tissues including kidney an...

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